Non-steroidal anti-inflammatory drugs (NSAIDs) may antagonist the antihypertensive effect. Concurrent use with sympathomimetics may reduce the antihypertensive effect Potassium-sparing diuretics: may lead to elevation of serum potassium. Concurrent administration of sublingual nitroglycerin, long-acting nitrates, beta-blockers or other antianginal agents with Amlodipine may produce additive antihypertensive and antianginal effects.