Proxilev Special Precautions

Hypersensitivity and other serious reactions: Serious and sometimes fatal reactions (for example, anaphylactic reactions) may occur after first or subsequent doses of Ciprofloxacin. Discontinue Ciprofloxacin at the first sign of skin rash, jaundice or any sign of hypersensitivity.
Hepatotoxicity: Discontinue immediately if signs and symptoms of hepatitis occur.
Clostridium difficile-Associated Diarrhea: Evaluate if colitis occurs.
QT Prolongation: Prolongation of the QT interval and isolated cases of torsade de pointes have been reported. Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval.
Risk of Aortic Aneurysm and Dissection: Epidemiologic studies report an increased rate of aortic aneurysm and dissection within two months following use of fluoroquinolones, particularly in elderly patients. The cause for the increased risk has not been identified. In patients with a known aortic aneurysm or patients who are at greater risk for aortic aneurysms, reserve Ciprofloxacin for use only when there are no alternative antibacterial treatments available.