Prostulax Overdosage

If overdose of Tamsulosin HCl lead to hypotension, support of the cardiovascular system is of first importance. Restoration of blood pressure and normalization of heart rate may be accomplished by keeping the patient in the supine position. If this measure is inadequate, then administration of intravenous fluids should be considered. If necessary, vasopressors should then be used and renal function should be monitored and supported as needed. Laboratory data indicate that Tamsulosin HCl is 94% to 99% protein bound; therefore, dialysis is unlikely to be of benefit. One patient reported an overdose of thirty 0.4 mg Tamsulosin HCl capsules. Following the ingestion of the capsules, the patient reported a severe headache. Measures, such as emesis can be taken to impede absorption. When large quantities are involved, gastric lavage can be applied and activated charcoal and an osmotic laxative, such as sodium sulfate, can be administered.