Proquad Dosage/Direction for Use

Dosage: Individuals 12 months through 12 years of age should receive a single dose of Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad) administered subcutaneously.
If a second dose of measles-containing vaccine is to be administered according to applicable official recommendations, then Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad) may be used for this dose.
If the first dose of a measles-containing vaccine is given between 6 months of age and less than 12 months of age (in an at-risk situation such as measles outbreak, or due to official recommendations) the response to the vaccine may be adversely influenced by circulating maternal antibodies. Therefore, another dose of a measles-containing vaccine should be given at 12 months of age or later. A subsequent (third) dose can be administered if warranted by official recommendations for a measles-containing vaccine.
At least 1 month should elapse between a dose of ATTENUVAX or M-M-R II and Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad). If for any reason a second dose of varicella-containing vaccine is required, at least 1 month should elapse between administration of the 2 doses.
Do not give immune globulin (IG) or Varicella Zoster Immune Globulin (VZIG) concomitantly with Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad) (see Interactions).
Method of Administration: FOR SUBCUTANEOUS ADMINISTRATION. DO NOT INJECT INTRAVASCULARLY.
The vaccine is to be injected in the deltoid region of the upper arm or in the higher anterolateral area of the thigh.
CAUTION: A sterile syringe free of preservatives, antiseptics, detergents, and other antiviral substances must be used for each injection and/or reconstitution of Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad) because these substances may inactivate the vaccine viruses.
To reconstitute the vaccine, use only the diluent supplied because it is free of preservatives or other antiviral substances, which might inactivate the vaccine viruses.
It is important to use a separate sterile syringe and needle for each patient to prevent transmission of infectious agents from one individual to another.
Withdraw the entire volume of solvent into a syringe. Inject the entire content of the syringe into the vial containing the powder. Gently agitate to dissolve completely. Withdraw the entire content of the reconstituted vaccine from the vial into the same syringe and inject the entire volume.
IT IS RECOMMENDED THAT THE VACCINE BE ADMINISTERED IMMEDIATELY AFTER RECONSTITUTION, TO MINIMIZE LOSS OF POTENCY. DISCARD IF RECONSTITUTED VACCINE IS NOT USED WITHIN 30 MINUTES.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Before reconstitution, the lyophilized vaccine is a white to pale yellow compact crystalline plug. Measles, Mumps, Rubella and Varicella (Oka/Merck) Virus Vaccine Live (ProQuad), when reconstituted, is a clear pale yellow to light pink liquid.