Increased risk of breast cancer w/ estrogen replacement therapy, DVT or pulmonary embolism. Patients w/ conditions that might be aggravated by fluid retention eg, HTN, cardiac disease, renal disease, epilepsy, migraine, asthma; history of depression, diabetes, mild to moderate hepatic dysfunction, migraine or photosensitivity & breastfeeding mothers. W/hold if explained, sudden or gradual, partial or complete loss of vision, proptosis or diplopia, papilloedema, retinal vascular lesions or migraine occurs. Hepatic & renal impairment. May affect ability to drive & use machinery. Women w/ existing or history of breast cancer; known risk factors of breast cancer eg, strong family history of breast cancer. Use of micronized progesterone during second & third trimesters of pregnancy can develop cholestatic jaundice of pregnancy or hepato-cellular liver disease. Pregnancy & lactation.
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