Probelin Special Precautions

Long term therapy should be avoided, particularly in infants and children as adrenal suppression can occur even without occlusion. If Clobetasol is required for use in children, it is recommended that the treatment should be reviewed weekly. It should be noted that the infant's napkin may act as an occlusive dressing.
The face, more than any other areas in the body may exhibit atrophic changes after prolonged treatment with potent topical corticosteroids.
If applied to the eyelids, care is needed to ensure that Clobetasol does not enter the eye as glaucoma might result. Topical steroids may be hazardous in psoriasis for a number of reasons including rebound relapses, development of tolerance, risk of generalized pustular psoriasis or a number of local or systemic toxicity due to impaired barrier function of the skin. If used in psoriasis, careful patient supervision is important.
Appropriate antimicrobial therapy should be used whenever treating inflammatory lesions which have become infected. Any spread of infection requires withdrawal of topical corticosteroid therapy and systemic administration of antimicrobial agents.