Vitamin C: Concurrent intake of more than 200 mg of Ascorbic acid per 300 mg of elemental iron would increase absorption of iron from the intestines. Increased urinary excretion of Ascorbic acid and decreased excretion of aspirin occur when these drugs are taken together. Taking Ascorbic acid with paracetamol can prolong the presence of paracetamol in the blood. Ascorbic acid is not compatible in solution with drugs like aminophylline, bleomycin, erythromycin, lactobionate, nafcillin, sodium nitrofurantoin, conjugated estrogens, sodium bicarbonate, sulfafurazole, diethanolamine, chloramphenicol sodium succinate, chlorothiazide sodium and hydrocortisone sodium succinate. Ascorbic acid has also been reported to interfere with blood-thinning treatments. Consult a doctor for advice before taking Ascorbic acid if patient is taking any of the previously mentioned medications.
Zinc: Zinc is known to have medicinal interactions with certain class of antimicrobials like cephalosporins, beta-lactam antibiotics, tetracyclines, antiretroviral drugs like atazanavir, ritonavir, antineoplastic agents like cisplatin, antidiabetic drugs like glimepiride, glyburide, pioglitazone, insulin and potassium-sparing diuretics like amiloride. The presence of other medical problems like copper deficiency may make the condition worse. Discuss with a physician the use of this medicine with food, alcohol, or tobacco.
Vitamin D3: Avoid taking Vitamin D3 if patient is taking the following drugs: Paricalcitol, Calcipotriene, Doxercalciferol, Mineral oil, Orlistat, Bile acid sequesterants like colesevelam, colestipol, cholestyramine.
Drugs like Orlistat, or bile acid sequesterants like those listed previously, can decrease or prevent the body from absorbing Vitamin D3 and other fat-dependent Vitamins A, E and K.
Take Vitamin D3 at least 2 hours apart from the previously mentioned list of drugs or take Vitamin D3 at bedtime to allow enough time to avoid interactions.
Also, be careful with drugs like: Digoxin; Aluminum hydroxide; Water pills like chlorthalidone, hydrochlorothiazide and chlorothiazide; Magnesium hydroxide and magnesium citrate; Fosphenytoin.
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