Polynerv 1000

Each film-coated tablet contains: Thiamine Mononitrate (Vitamin B1) 250 mg, Pyridoxine Hydrochloride (Vitamin B6) 250 mg, Cyanocobalamin (Vitamin B12) 1 mg (eq. to 1000 mcg).
Vitamin B1+ B6 + B12 (POLYNERV 1000) contains the neurotrophic agents B1, B6 and B12 which act in a concerted effort to help enhance efficient functioning of the nervous system. This potent combination of the major B-complex is specifically valuable in the comprehensive management of neuropathies.

Pharmacology: Pharmacodynamics: Vitamin B1 + B6 + B12 as coenzymes, activate the metabolic processes by which the breakdown products of carbohydrates, fats and proteins are further transformed and utilized by the different body cells.
Vitamin B1 + B6 + B12 therefore stimulate the various metabolic processes of the body which produce the energy needed to fuel the cellular activities of the body, specially the physiologic activities of the nervous system.
Thiamine Mononitrate (B1) as a coenzyme of glucose metabolism ensures the efficient production of energy from glucose and the conversion of glucose into other metabolites such as ribose, a major component of DNA and RNA. The cells of the nervous system depend entirely on glucose as its energy source. Independent of its coenzyme function, thiamine acts as a modulator in neuromuscular transmission.
Vitamin B1 + B6 + B12 (POLYNERV 1000) with its high concentration of pyridoxine hydrochloride is involved in various metabolic transformations of amino acids needed for tissue building and repair and in the biosynthesis of neurotransmitters and blood elements.
Vitamin B1 + B6 + B12 (POLYNERV 1000) gives high amount of cyanocobalamin, a coenzyme which promotes metabolism of nucleic acids and some fatty acids necessary for formation of new cells.
The substantial concentration of B1 + B6 + B12 in POLYNERV 1000 will ensure optimum nutrition of neuronal cells essential for a more efficient functioning of the neuromuscular system.
Pharmacokinetics: Following oral administration, thiamine is absorbed from the gastrointestinal tract and is widely distributed to most body tissues. Thiamine is mostly present within the cells as diphosphate. Thiamine is not stored in the body and amounts in excess of the body's requirements are excreted in the urine as unchanged thiamine or as metabolites.
Pyridoxine is readily absorbed from the gastrointestinal tract. It is converted to the active form pyridoxal phosphate and is stored mainly in the liver. Amounts in excess of the body's requirements are excreted unchanged in the urine. Pyridoxal diffuses across the placenta and appears in breast milk.
Vitamin B12 compounds which bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa are then actively absorbed from the gastrointestinal tract. Little amount is absorbed by passive diffusion but the process becomes increasingly important with larger or therapeutic amounts.
Vitamin B12 is extensively bound to transcobalamin, a plasma protein. Vitamin B12 is stored in the liver and excreted in the bile. Part of a dose is excreted in the urine. Vitamin B12 diffuses across the placenta and is also distributed into breast milk.

For the prophylaxis and treatment of vitamin B1, B6 and B12 deficiencies associated with restricted diet, illnesses, impaired absorption and utilization of B vitamins resulting from prolonged antibiotic therapy and intake of certain drugs. As adjuvant or support in the comprehensive management of neuritis, polyneuritis, neuralgia, diabetes, alcoholism and drug induced neuropathies, hyperemesis gravidarum, optic neuritis, facial paresis, trigeminal neuralgia, shoulder-arm syndrome, herpes zoster, lumbago, numbness of the extremities, sciatica.

Prophylactic: 1-2 tablets daily.
Therapeutic: 2-4 tablets daily.
Or as prescribed by the physician.

Contraindicated in patients with history of hypersensitivity to the components. Cyanocobalamin should not be given to patients with suspected vitamin B12 deficiency without confirmation of the diagnosis.

Cyanocobalamin (Vitamin B12) should not be used to treat megaloblastic anemia of pregnancy.
Administration of doses greater than 10 mcg of Vitamin B12 daily may produce a haematological response in patients with folate deficiency; indiscriminate use may mask the precise diagnosis. Cyanocobalamin or hydroxocobalamin should, if possible, not be given to patients with suspected vitamin B12 deficiency without first confirming the diagnosis. Regular monitoring of the blood is advisable.

Use in Pregnancy: Cyanocobalamin (Vitamin B12) should not be used to treat megaloblastic anemia of pregnancy.

Adverse effects seldom occur after oral administration of thiamine and cyanocobalamin, but hypersensitivity reactions have been reported after parenteral administration. Hypersensitivity reactions to thiamine ranged from very mild to very rarely, anaphylactic shock. Hypersensitivity reactions have occurred rarely following oral administration of cyanocobalamin.
Long-term administration of large doses of pyridoxine is associated with the development of severe peripheral neuropathies.

Drugs that increase the requirements for pyridoxine include hydralazine, isoniazid, penicillamine and oral contraceptives, neomycin, aminosalicylic acid, histamine H2-antagonists and colchicine may reduce the absorption of vitamin B12 from the gastrointestinal tract. Oral contraceptives may reduce serum concentrations of vitamin B12. Though unlikely to be of clinical significance, many interactions of vitamin B12 should be taken into account when performing assays for blood concentration.

Store at temperatures not exceeding 30°C.

Vitamin B-Complex / with C

A11DB - Vitamin B1 in combination with vitamin B6 and/or vitamin B12 ; Used as dietary supplements.

Non-Rx