Pneumocon 13 Description

The Pneumococcal Polysaccharide Conjugate Vaccine, 13-Valent (Adsorbed) (PCV13-TT) is formulated by compounding the capsular polysaccharide antigen of Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, individually conjugated to tetanus toxoid carrier protein. The individual polysaccharides are extracted from the cultures of Streptococcus pneumoniae, and purified through centrifugation, precipitation, and ultrafiltration. The polysaccharides are chemically activated and derivatized, and then conjugated to tetanus toxoid carrier protein to form the glycoconjugate, with aluminum phosphate as the adjuvant. The vaccine should be shaken well to obtain a homogeneous milky white suspension. During storage, a white deposit and clear supernatant might be observed due to adjuvant precipitation.
Active substances: Capsular polysaccharides of Streptococcus pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F conjugated to tetanus toxoid carrier protein.
Excipients/Inactive Ingredients: Sodium chloride, sodium dihydrogen phosphate monohydrate, disodium hydrogen phosphate dodecahydrate, aluminum phosphate and water for injection.
Each dose (0.5 mL) of the vaccine contains: See Table 1.

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