Plavix Indications/Uses

Clopidogrel is indicated in adults for the secondary prevention of atherothrombotic events in: Recent MI, Recent Stroke or Established Peripheral Arterial Disease: For patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease, clopidogrel has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular death.
Acute Coronary Syndrome: For patients with Non-ST-segment elevation acute coronary syndrome (unstable angina/non-Q-wave myocardial infarction [MI]) including patients who are to be managed medically and those who are to be managed with percutaneous coronary intervention (with or without stent) or CABG, clopidogrel has been shown to decrease the rate of a combined endpoint of cardiovascular death, MI, or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia.
For patients with ST-segment elevation acute myocardial infarction, clopidogrel has been shown to reduce the rate of death from any cause and the rate of a combined endpoint of death, re-infarction or stroke. For patients with ST segment elevation acute myocardial infarction, in combination with ASA in patients undergoing percutaneous coronary intervention or medically treated patients eligible for thrombolytic/fibrinolytic therapy.
In patients with moderate to high-risk Transient Ischemic Attack (TIA) or minor Ischemic Stroke (IS): Clopidogrel in combination with ASA is indicated in: Adult patients with moderate to high-risk TIA (ABCD2¹ score ≥4) or minor IS (NIHSS² ≤3) within 24 hours of either the TIA or IS event.
Clopidogrel is indicated in adults for the prevention of atherothrombotic and thromboembolic events in: Atrial Fibrillation: In patients with atrial fibrillation (AF) at increased risk of vascular events who can take vitamin K antagonist (VKA) therapy, VKA has been shown to be associated with a better clinical benefit than acetylsalicylic acid (ASA) alone or the combination of clopidogrel and ASA for the reduction of stroke.
In patients with atrial fibrillation who have at least one risk factor for vascular events and who cannot take VKA therapy (e.g., specific risk of bleeding, physician assessment that patient is unable to comply with INR (international normalised ratio) monitoring or that VKA use is inappropriate), clopidogrel is indicated in combination with ASA for the prevention of atherothrombotic and thromboembolic events, including stroke. Clopidogrel in combination with ASA has been shown to reduce the rate of the combined endpoint of stroke, myocardial infarction (MI), non-CNS systemic embolism, or vascular death, largely through a reduction in stroke.
¹ Age, Blood pressure, Clinical features, Duration, and Diabetes mellitus diagnosis.
² National Institutes of Health Stroke Scale.