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Acute Coronary Syndrome: In patients who need an antiplatelet effect within hours, initiate Clopidogrel with a single 300-mg oral loading dose and then continue at 75 mg once daily. Initiating Clopidogrel without a loading dose will delay establishment of an antiplatelet effect by several days.
Recent MI, Recent Stroke, or Established Peripheral Arterial Disease: 75 mg once daily orally without a loading dose.
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