Philcet Plus Description

Each film-coated tablet contains: Montelukast (as sodium) 10 mg, Levocetirizine Hydrochloride 5 mg.
Montelukast Sodium: Montelukast sodium, the active ingredient in montelukast sodium tablets, is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene CysLT1 receptor.
Montelukast sodium is described chemically as: [R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1 methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid, monosodium salt.
The empirical formula is C₃₅H₃₅ClNNaO₃S, and its molecular weight is 608.18.
Montelukast sodium is a hygroscopic, optically active, white to off-white powder. Montelukast sodium is freely soluble in ethanol, methanol, and water and practically insoluble in acetonitrile.
Levocetirizine hydrochloride: Levocetirizine hydrochloride, the active component of levocetirizine hydrochloride tablets, is an orally active H1-receptor antagonist. The chemical name is (R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid hydrochloride. Levocetirizine hydrochloride is the R enantiomer of cetirizine hydrochloride, a racemic compound with antihistaminic properties. The empirical formula of levocetirizine hydrochloride is C₂₁H₂₅ClN₂O₃•2HCl. The molecular weight is 461.82.
Levocetirizine hydrochloride is a white, crystalline powder and is water soluble.