Pantoprazole is a proton pump inhibitor with actions and uses similar to those of omeprazole. It is given as the sodium salt but doses are expressed in terms of the base. Pantoprazole is indicated for the prevention of relapse in patients with reflux esophagitis, indicated for short-term (up to 4 weeks) treatment for symptom relief and healing in patients with active duodenal ulcer and up to 8 weeks treatment in patients with active benign gastric ulcer. Pantoprazole is indicated for short-term treatment (7 to 10 days) of adult patients with Gastroesophageal Reflux Disease (GERD) and a history of erosive esophagitis. Safety and efficacy of pantoprazole as a treatment for patients with GERD and a history of erosive esophagitis for more than 10 days have not been demonstrated.
In combination with clarithromycin and either amoxicillin or metronidazole, it is indicated for treatment of patients with an active duodenal ulcer who are Helicobacter pylori positive.
Pantoprazole is also indicated for the treatment of pathological hypersecretory conditions associated with Zollinger-Ellison syndrome in adults. The drug reduces the volume of gastric acid output and hydrogen ion concentration of gastric secretions in patients with these conditions.
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