Pantovaz Description

Each Enteric-Coated Tablet contains Pantoprazole (as sodium sesquihydrate), USP 40 mg.
The active ingredient in Pantoprazole sodium sesquihydrate for delayed-release tablet is substituted benzimidazole, sodium 5-(difluromethoxy)-2[[3,5-dimethoxy-2 pyridinyl) methyl]methyl] sulfinyl] 1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid secretion. Its empirical formula is C₁₆H₁₄F₂N₃NaO₄S x 1.5 H₂O, with a molecular weight of 432.4. Pantoprazole sodium sesquihydrate is a white to off-white crystalline powder and is racemic. Pantoprazole has weekly basic and acidic properties. Pantoprazole sodium as sesquihydrate is freely soluble in water, very slightly soluble in phosphate buffer at pH 7.4, and practically insoluble in n-hexane.
Pantoprazole sodium sesquihydrate is proton pump inhibitor. It inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphate (H+/K+-ATPase), the "proton pump" of the gastric parietal cell. It is used in conditions where inhibition of the gastric acid secretion may be beneficial, including aspiration syndromes, dyspepsia, gastro-esophageal reflux disease, peptic ulcer disease and the Zollinger-Ellison syndrome.