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Gastric and duodenal ulcer, reflux esophagitis: The recommended intravenous dose is one vial of Pantoprazole injection 40 mg once daily by IV infusion for 7 to 10 days.
Zollinger-Ellison Syndrome and other conditions producing too much acid in the stomach: It should start the treatment with a daily dose of 80 mg. Thereafter, the dose can be titrated up or down as needed using measurements of gastric acid secretion to guide.
With dose about 80 mg daily, the dose should be divided and given twice daily.
A temporary increase of the dose above 160 mg of Pantoprazole is possible but should not be applied longer than required for adequate acid control.
In case a rapid acid control is required, a starting dose of 2 x 80 mg is sufficient to manage a decrease of acid output into the target range (<10 mEq/h) within one hour in the majority of patients.
A daily dose of 20 mg pantoprazole should not be exceeded in patients with severe liver impairment.
A daily dose of 50 mg pantoprazole should not be exceeded in elderly and renal impairment patients.
Preparation of Dosage Form: The content of the vial should be reconstituted with 10 mL of 0.9% Sodium Chloride for Injection. The prepared solution should be administered intravenously either as a slow injection or it may be further diluted with 100 mL of 0.9% Sodium Chloride Injection or 5% Glucose Injection and administered as a short term infusion. The duration of administration should be 2 to 15 minutes. The reconstituted solution must be used within 12 hours of preparation.
Note: Intravenous administration of Pantoprazole is recommended only if oral administration is not appropriate. As soon as oral therapy is possible, treatment with Pantoprazole injection should be discontinue.
