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5 mL & 16.67 mL: Primary anticipated complications of paclitaxel overdosage consist of bone marrow suppression, peripheral neurotoxicity and mucositis. Pediatric overdose may be attributed to the alcohol content of the formulation. There is no known antidote for paclitaxel overdosage. Treatment is symptomatic and supportive. Discontinue paclitaxel and initiate appropriate supportive measures for the type of toxicity observed. Only a minimal portion of paclitaxel is removed by hemodialysis.
43.4 mL: There is no antidote for Paclitaxel (Paclib) overdosage. The primary anticipated complications of overdosage would consist of bone marrow suppression, peripheral neurotoxicity, and mucositis.
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