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There is no clinical experience of overdosage only isolated cases of overdose with letrozole have been reported. In animal studies, letrozole exhibits only a slight degree of acute toxicity. In clinical trials, the highest single and multiple dose tested in healthy volunteers was 30 mg and 5 mg, respectively, the latter also being the highest dose tested in postmenopausal breast cancer patients. Each of these doses was well tolerated. There is no clinical evidence for a particular dose of letrozole resulting in life-threatening symptoms.
There is no specific antidote to letrozole. In general, supportive care, symptomatic treatment and frequent monitoring of vital signs are appropriate.
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