Initiation & maintenance of monitored anesth care (MAC) sedation, combined sedation & regional anesth, ICU sedation of intubated, mechanically ventilated patients in adults only. Induction & maintenance of general anaesth for patients ≥3 yr.
Induction of general anesthAdult <55 yr 2-2.5 mg/kg. Elderly, debilitated, ASA-PS III or IV patients 1-1.5 mg/kg. Cardiac anesth 0.5-1.5 mg/kg. Neurological patient 1-2 mg/kg. Maintenance of general anesth Infusion Adult <55 yr 6-12 mg/kg/hr. Elderly, debilitated, ASA-PS III or IV patient 3-6 mg/kg/hr. Cardiac anesth: 100-150 mcg/kg/min as primary inj emulsion w/ secondary opioid; 50-100 mcg/kg/min for low-dose propofol inj emulsion w/ primary opioid. Neurological patient 6-12 mg/kg/hr.Pediatric 2 mth-16 yr 7.5-18 mg/kg/hr. Intermittent bolus Adult <55 yr 20-50 mg. Initiation of MAC sedationAdult <55 yr 6-9 mg/kg/h infusion for 3-5 min or 0.5 mg/kg slow inj for 3-5 min. Maintenance of MAC sedation Adult <55 yr 1.5-4.5 mg/kg/hr infusion or 10 or 20 mg incremental bolus. Elderly, debilitated, ASA-PS III or IV patient 80% of usual adult dose. Initiation & maintenance of ICU sedation of intubated, mechanically ventilated Adult Initially 5 mcg/kg/min for at least 5 min. Subsequent increments of 5-10 mcg/kg/min for 10-15 min. Maintenance rate: 5-50 mcg/kg/min.
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