Adult >18 yrSchizophrenia, combination therapy for mania, recurrence prevention in bipolar disorder 10 mg daily, may be adjusted to 5-20 mg daily. Give >15 mg doses only after reassessment. Max: 20 mg daily.
May enhance central effects of other CNS depressants including alcohol. May antagonize effects of dopaminergics. Neutropenia may be more common w/ valproate. Theoretical risk of QT prolongation w/ other drugs known to prolong the QT interval. Plasma conc may be affected w/ CYP1A2 inhibitors, inducers or substrates. Inhibited metabolism w/ fluvoxamine (CYP1A2 inhibitor). Increased clearance w/ tobacco, smoking & carbamazepine.
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