Noston Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

K citrate

Indications/Uses

Management of renal tubular acidosis w/ Ca stones; hypocitraturic Ca oxalate nephrolithiasis of any etiology; uric acid lithiasis w/ or w/o Ca stones. Prevention of stone relapse after extracorporeal shock wave lithotripsy or lithotomy.

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Dosage/Direction for Use

Severe hypocitraturia (urinary citrate <150 mg/day) 60 mEq/day in 2 or 3 divided doses (20 mEq tid or 30 mEq bid). Mild to moderate hypocitraturia (urinary citrate >150 mg/day) 30 mEq/day in 2 or 3 divided doses (10 mEq tid or 15 mEq bid).

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Overdosage

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Administration

Should be taken with food: Take tab 30 min after meals. Swallow whole, do not crush/chew/suck. Avoid food w/ high salt content. Increase fluid intake.

Contraindications

Hypersensitivity. Patients w/ hyperkalemia or conditions predisposing them to hyperkalemia eg, chronic renal failure, uncontrolled DM, familial hyperkalemic periodic paralysis (adynamia episodica hereditaria), acute dehydration, strenuous physical exercise in unconditioned individuals, adrenal insufficiency, extensive tissue breakdown, severe myocardial damage, administration of K-sparing diuretic (eg, triamterene, spironolactone or amiloride); slow gastric emptying, esophageal compression, intestinal obstruction or stricture; active PUD; active UTI (w/ either urea-splitting bacteria or other organisms, in association w/ either Ca or struvite stones); renal insufficiency (GFR <0.7 mL/kg/min); resp or metabolic acidosis. Patients on anticholinergic therapy.

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Special Precautions

Discontinue treatment in the occurrence of hyperkalemia, a significant rise in serum creatinine, or a significant fall in blood hematocrit or Hb. Immediately discontinue treatment & investigate for possibility of bowel perforation or obstruction in the event of severe vomiting, abdominal pain or GI bleeding. Regular serum K monitoring is recommended. Periodically determine acid-base balance, other serum electrolyte levels, & ECG. Careful attention should be given to patient's clinical status, particularly in the presence of cardiac disease, renal disease or acidosis. Can produce hyperkalemia & cardiac arrest in patients w/ impaired mechanisms for K excretion. Give to pregnant woman only if clearly needed. Caution in breastfeeding woman. Safety & efficacy in childn have not been established.

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Use In Pregnancy & Lactation

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Adverse Reactions

Minor GI complaints eg, abdominal discomfort, vomiting, diarrhea, loose bowel movements & nausea.

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Drug Interactions

Severe hyperkalemia w/ K-sparing diuretics (eg, triamterene, spironolactone, or amiloride). Increased GI irritation caused by K salts w/ drugs that slow GI transit time (eg, anticholinergics).

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Storage

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Description

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Action

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MIMS Class

Other Drugs Acting on the Genito-Urinary System

ATC Classification

A12BA02 - potassium citrate ; Belongs to the class of potassium-containing preparations. Used as dietary supplements.

Regulatory Classification

Presentation/Packing

Form

Noston ER tab 1.08 g (10 mEq)

Packing/Price

30's

Form

Noston ER tab 1.62 g (15 mEq)

Packing/Price

30's

Noston

potassium citrate

Manufacturer:

Nucare Labs

Distributor:

ECE Pharma

Marketer:

4Life Healthcare