Not administered as a rule, but in particular necessity, administer carefully for following patients: Patients with cocaine poisoning (use of cocaine can enhance the central action and sympathetic stimulation and weakened the symptoms); Patients with ventricular tachycardia (the symptoms may be exacerbated by the reduction of cardiac output and the cerebral blood flow).
Patients with atherosclerosis (Elevate blood pressure and reduce peripheral blood flow).
Patients with heart disease (may affect cardiac function).
Patients with bradycardia (may cause arrhythmia).
Patients of coronary, mesenteric, peripheral vascular thrombosis patients (there is a risk of ischemia and increase area of infarction).
Patients with hypotension due to myocardial infarction.
Patients with Prinzmetal angina.
Elders.
Allergies such as anaphylaxis can be appeared since it contains sodium sulfite, and some sensitive patients may represent a much weaker or even in life-threatening asthma. Overall incidence of sulfite sensitivity is unknown but low in general people and sulphite sensitivity is frequent in patients with asthma than non-asthmatics.
Use in the Elderly: Carefully administer due to the possibility of excessive increase in blood pressure.
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