Nicardin Use In Pregnancy & Lactation

Pregnancy: Limited pharmacokinetic data have shown that Nicardipine i.v. dose not accumulate and has a low placental transfer.
In clinical practice, the use of Nicardipine hydrochloride during the first two trimesters in a limited number of pregnancies has not revealed any malformative or particular foetotoxic effect to date.
The use of Nicardipine hydrochloride for severe pre-eclampsia during the third trimester of pregnancy could potentially produce an undesirable tocolytic effect which could potentially interfere with the spontaneous induction of labour.
Acute pulmonary oedema has been observed when Nicardipine hydrochloride has been used as tocolytic during pregnancy, especially in cases of multiple pregnancy (twins or more), with the intravenous route and/or concomitant use of beta-2 agonists. Nicardipine hydrochloride should not be used in multiple pregnancies or in pregnant women with compromised cardio-vascular condition, except if there is no other acceptable alternative.
Lactation: Nicardipine hydrochloride and its metabolites are excreted in human milk at very low concentration. There is insufficient information on the effects of nicardipine in newborns/infants. Nicardipine hydrochloride should not be used during breast-feeding.
Fertility: No data.