Nexpro-20/Nexpro-40/Nexpro IV Dosage/Direction for Use

Nexpro-20/Nexpro-40: Gastro-esophageal Reflux Disease (GERD): treatment of erosive reflux oesophagitis 40mg once daily for 4 weeks. An additional 4 weeks treatment is recommended for patients in whom esophagitis has not healed or who have persistent symptoms.
Long-term management of patients with healed esophagitis to prevent relapse 20mg once daily.
Symptomatic treatment of gastro-esophageal reflux disease (GERD) 20mg once daily in patients without esophagitis. If symptom control has not been achieved after 4 weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using an on demand regimen, taking 20mg once daily, when needed.
Patients requiring continued NSAID therapy: prevention of gastric and duodenal ulcers associated with NSAID therapy in patients at risk: 20 mg or 40mg once daily.
In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori: healing of Helicobacter pylori associated duodenal ulcer.
Prevention of relapse of peptic ulcers in patients with Helicobacter pylori associated ulcer disease. 20mg Esomeprazole with 1 g amoxicillin and 500mg clarithromycin, all twice daily for 7 days.
Children: There is no experience with Esomeprazole in children.
Impaired renal function: Dose adjustment is not required in patients with impaired renal function. Due to limited experience in patients with severe renal insufficiency, such patients should be treated with caution.
Impaired hepatic function: Dose adjustment is not required in patients with mild to moderate liver impairment. For patients with severe liver impairment, a maximum daily dose of 20 mg Esomeprazole should be used.
Elderly: Dose adjustment is not required in the elderly.
Directions for Use: The tablets should be swallowed whole with liquid. The tablets should not be chewed or crushed.
The tablets can also be dispersed in half a glass of non-carbonated water. No other liquids should be used. Stir until the tablets disintegrate and drink the liquid with the pellets immediately or within 30 minutes. Rinse the glass with half a glass of water and drink. For patients who cannot swallow, the tablets can be dispersed in non-carbonated water and administered through a gastric tube.
Nexpro IV: The recommended adult dose of Esomeprazole I.V is either 20 or 40 mg given once daily by intravenous injection (no less than 3 minutes) or intravenous infusion (10 to 30 minutes). Esomeprazole I.V. should not be administered concomitantly with any other medications through the same intravenous site and/or tubing. The intravenous line should always be flushed with either 0.9% Sodium Chloride Injection USP, Lactated Ringer Injection USP, or 5% Dextrose Injection USP, both prior to and after administration of Esomeprazole I.V. for Injection. Or as Prescribed by the physician.
DIRECTION FOR RECONSTITUTION: Reconstitute with 10 mL of 0.9% Sodium Chloride Injection.