Neurocil

Each capsule contains: Citicoline (as sodium) 500 mg.
Citicoline is a derivative of choline and cytidine that is involved in the biosynthesis of lecithin. It is claimed to increase blood flow and oxygen consumption in the brain and has given in the treatment of cerebrovascular disorders, parkinsonism and head injury. Citicoline is an interneuronal communication enhancer. It increases the neurotransmission levels because it favors the synthesis and production speed of dopamine in the striatum, acting then as a dopaminergic agonist thru the inhibition of tyrosine-hydroxylase. Citicoline acts as a presynaptic cholinergic agent which favors the synthesis of acetylcholine. It also decreases the release of serotonin. Citicoline makes the neuron more active, causing astrocytes to loosen their grip on the capillaries, thus improving microcirculation. It has the ability to slightly increase cerebral blood flow and exerts an anti-aggregation effect on the platelets.

Psychoanaleptics (other psychostimulants and nootropics).
Pharmacology: Pharmacodynamics: When administered orally, it is absorbed almost completely and its bioavailability is approximately the same when administered IV. Once absorbed, cytidine and choline disperse widely throughout the body, cross the blood-brain barrier and reach the CNS, where they are incorporated into the phospholipid fraction of the cellular membrane and microsomes. The concept that administration of exogenous citicoline can augment the synthesis of neural membrane phospholipid is attractive, because accelerated replacement or repair plays a critical role in maintaining the healthy function of numerous physiological processes. It has shown therapeutic efficacy in a variety of diseases in which membrane disorder, dysfunction or degeneration result in cellular and tissue ischemia and necrosis.

It is used to increase blood flow and oxygen consumption in the brain and for treatment of cerebrovascular disorders, (including ischaemic stroke), Parkinsonism and head injury.
Acute and recovery phase of cerebral infection (e.g., ischemia due to stroke).
Cognitive dysfunction due to degenerative (i.e. Alzheimer's disease) and cerebrovascular disease.
Cerebral insufficiency (e.g. dizziness, memory loss, poor concentration, disorientation) due to head trauma or brain injury. Parkinson's disease.

By mouth in divided doses of 20 mg to 60 mg daily or as prescribed by the physician.
Citicoline 500 mg capsule: once or twice a day or as prescribed by the physician.

Must not be administered to patients with hypertonia of the parasympathetic.

Citicoline must not be administered along with medicaments containing meclophenoxate.

Increased parasympathetic effects, fleeting and discrete hypotensor effect.

Citicoline potentiates the effects of L-dopa.

Store at temperatures not exceeding 30°C.

Other CNS Drugs & Agents for ADHD

N06BX06 - citicoline ; Belongs to the class of other psychostimulants and nootropics.

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