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Vitamin B6 (pyridoxine) may decrease the effect of L-DOPA.
Pyridoxine antagonists such as isoniazid, cycloserine, penicillamine, or hydralazine may decrease the efficacy of vitamin B6 (pyridoxine).
Long-term use of loop diuretics such as furosemide may accelerate the elimination and thus decrease the serum levels of vitamin B1 (thiamine).
Long-term use of acid-lowering agents may lead to vitamin B12 deficiency.
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