Hypersensitivity to nebivolol HCl or to any of the components of Nebil. Severe hepatic insufficiency; acute heart failure, cardiogenic shock or episodes of heart failure decompensation requiring IV inotropic therapy. Sick sinus syndrome including sino-atrial block; 2nd- and 3rd- degree heart block (without a pacemaker); history of bronchospasm and bronchial asthma; untreated phaeochromocytoma; metabolic acidosis; bradycardia (heart rate <60 bpm prior to start of therapy); hypotension (systolic blood pressure <90 mmHg); severe peripheral circulatory disturbances.