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Pharmacology: Nadifloxacin is an antimicrobial drug for the topical treatment of defined forms of acne. Nadifloxacin is a synthetic bactericidal quinolone with a broad spectrum of antibacterial activity against aerobic Gram-positive, aerobic Gram-negative and anaerobic bacteria, including Propionibacterium acnes and Staphylococcus epidermidis. Nadifloxacin has shown a high antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), with similar strength to methicillin sensitive Staphylococcus aureus (MSSA). It is also effective against recently emerged MRSA quinolone-resistant.
Mechanism of Action: The bactericidal action of Nadifloxacin results from the inhibition of the DNA gyrase (topoisomerase II) and topoisomerase IV bacterial enzymes. These enzymes are essential for the replication, transcription and repair of bacterial DNA.
The metabolism is produced by oxidation and conjugation processes. No cross-resistances of Nadifloxacin to other new quinolones have been observed.
