Mytoxid Dosage/Direction for Use

Intermittent Administration: 4-6 mg of Mitomycin daily, once or twice a week intravenously.
Continuous Administration: 2 mg of Mitomycin, daily intravenously.
Massive Intermittent Administration: 10-30 mg daily at 1- to 3-week intervals or more intravenously.
Concomitant Administration with Other Antineoplastics: 2-4 mg of Mitomycin is given concomitantly with other antineoplastic agents daily, every one to two weeks.
For administration to specific cases, 2-10 mg of Mitomycin can be given also into the pleural and peritoneal cavities and by the arterial route.
Bladder Tumors: In the prevention of recurrent bladder tumors, the usual dose is the equivalent of 4-10 mg of Mitomycin instilled into the bladder once a day or every two days.
In the treatment of bladder tumors, the usual dose is the equivalent of 10-40 mg of Mitomycin instilled into the bladder once a day.
In I.V injection, maximum dosage a day is 30 mg.
Dosage of Mitomycin must be based on age and condition of the patient.
For reconstitution, the contents of the 10 mg vial should be dissolved in 20 mL water for injection. It is stable at room temperature for 7 days and 14 days when refrigerated (2-8°C) or as prescribed by the physician.