Childn >6 yr (18-40 kg) 5 mL tid, may be increased up to 50 mg/kg daily in divided doses every 8 hr in severe infections. Childn <12 mth 25 mg/kg daily eg, 7.5-kg child would require 2 mL tid.
May be taken with or without food: Best taken at start of meal for optimised absorption.
Contraindications
History of allergic reaction to β-lactams (eg, penicillins or cephalosporins). Patients w/ previous history of co-amoxiclav associated jaundice/hepatic dysfunction.
Not to be used w/ drugs that delay peristalsis (eg, opiates & diphenoxylate w/ atropine), which may prolong &/or worsen condition. Provide fluids, electrolytes & protein replacement therapy when indicated. Patients w/ evidence of hepatic dysfunction. Contains aspartame; patients w/ phenylketonuria. Avoid use in pregnancy, especially during 1st trimester, unless considered essential. Lactation.
May precipitate disulfiram-like (antabuse) reaction w/ alcohol. Amoxicillin: Transient decrease in plasma conc of total conjugated estriol & estradiol to pregnant women. Decreased renal tubular secretion that may result in increased & prolonged blood levels w/ probenecid. May increase incidence of rashes in patients receiving allopurinol.
J01CR02 - amoxicillin and beta-lactamase inhibitor ; Belongs to the class of penicillin combinations, including beta-lactamase inhibitors. Used in the systemic treatment of infections.
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