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Hypersensitivity to isosorbide-5-mononitrate or to other nitrates/nitrites or any component in the formulation.
Acute circulatory failure associated with marked hypotension (shock and states of collapse); angle-closure glaucoma; functional or organic gastrointestinal hypermotility or malabsorption syndrome; increased intracranial pressure (eg, head trauma or cerebral hemorrhage); myocardial insufficiency due to obstruction (eg, in the presence of aortic or mitral stenosis or of constrictive pericarditis); obstructive hypertrophic cardiomyopathy; pericarditis; hypotension and/or cardiogenic shock; postural or orthostatic hypotension; severe anemia; concurrent therapy with phosphodiesterase-5 (PDE-5) inhibitors (eg, sildenafil, tadalafil, vardenafil) since severe, potentially fatal hypotensive episodes can occur.
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