Metvex Adverse Reactions

Metoclopramide is a dopamine antagonist and may extrapyramidal symptoms which usually occur as acute dystonic reactions; these are more common in children and young adults, especially if female, and at daily doses above 500 μg per kg body-weight. Parkinsonism and tardive dyskinesia have occasionally occurred, usually during prolonged treatment in elderly patients. Other adverse effects include restlessness, drowsiness, and diarrhea. Hypotension, dizziness, headache, and depression may occur and there are isolated reports of blood disorders, hypersensitivity reactions, and neuroleptic malignant syndrome. Disorders of cardiac conduction have been reported with intravenous metoclopramide. Metoclopramide stimulates prolactin secretion and may cause galactorrhoea or related disorders. Transient increases in plasma-aldosterone concentrations have been reported.