Metfor XR Adverse Reactions

500 mg: In post marketing data and in controlled clinical studies, Metformin Hydrochloride Extended Release Tablets and Metformin Hydrochloride immediate release were similar in nature and severity in adverse event reporting in patients.
During treatment initiation, the most common adverse reactions are nausea, vomiting, diarrhea, abdominal pain and loss of appetite, which are resolved spontaneously in most cases.
The following adverse reactions may occur with Metformin Hydrochloride Extended Release Tablets.
Frequencies are defined as follows: very common: ≥1/10; common: ≥1/100, <1/10; uncommon: ≥1/1,000, <1/100; rare: ≥1/10,000, <1/1,000; very rare: <1/10,000.
Within each frequency grouping, adverse reactions are presented according to decreasing seriousness.
Metabolism and nutrition disorders: Common: Decrease or deficiency in Vitamin B12 levels.
Very rare: Lactic acidosis.
Nervous system disorders: Common: Taste disturbance.
Gastrointestinal disorders: Very common: Gastrointestinal disorders (such as nausea, vomiting, diarrhea, abdominal pain and loss of appetite).
These undesirable effects occur most frequently during the start of the therapy and mostly resolved spontaneously. A gradual increase of the dose may also enhance gastrointestinal tolerability.
Hepatobiliary disorders: Very rare: Isolated reports of liver function tests abnormalities or hepatitis that usually resolves upon metformin discontinuation.
Skin and subcutaneous tissue disorders: Very rare: Skin reactions (such as erythema, pruritus, urticaria).
Reporting of suspected adverse reactions: Reporting suspected adverse reactions after authorization of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the national reporting system.
750 mg: Diarrhea, abnormal stools, hypoglycemia, myalgia, light-headedness, dyspnea, nail disorder, rash, sweating increased, taste disorder, chest discomfort, chills, flu syndrome, flushing, and palpitations.