Dose is given by slow inj (over 3-5 min) or infusion (over 15-30 min). Adult 0.5-1 g every 8 hr. Meningitis Increased to 2 g every 8 hr. Cystic fibrosis Up to 2 g every 8 hr. Childn >3 mth & weighing <50 kg 10-20 mg/kg every 8 hr. Meningitis Increased to 40 mg/kg every 8 hr. Cystic fibrosis 25-40 mg/kg every 8 hr. Renal impairment CrCl 26-50 mL/min Usual dose every 12 hr, 10-25 mL/min ½ usual dose every 12 hr, <10 mL/min ½ usual dose every 24 hr.
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