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Injection: Symptoms of acute overdose may include: nausea, vomiting, abdominal pain, numbness, tingling of the extremities, rise in blood pressure, in severe cases followed by hypotension, respiratory depression, hypothermia, convulsions, and coma.
Removal of offending drug by including emesis, gastric lavage, cartharsis and supportive diuresis.
Maintenance of adequate pulmonary ventilation, especially if convulsions or coma develop.
Correction of hypotension with pressor drugs as needed.
Control of convulsions with standard anticonvulsant agents.
Control of peripheral vasospasm with warmth to the extremities if needed.
