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Use of biguanide concomitantly with other drugs that lower blood-glucose concentrations increases the risk of hypoglycemia, while drugs that increase blood glucose may reduce the effect of biguanide therapy.
In general, fewer drug interactions have been reported with biguanides than with sulfonylureas. Alcohol may increase the risk of lactic acidosis as well as of hypoglycemia. Care should be taken if biguanides are given concomitantly with drugs that may impair renal function.
