The most frequently reported symptoms of ibuprofen overdose include abdominal pain, nausea, vomiting, fatigue (lethargy) and drowsiness. Other symptoms include headache, ringing in the ears (tinnitus), central nervous system depression, convulsions, low blood pressure, and irregular heartbeat. Excessive acidity of the blood (metabolic acidosis), coma, acute kidney failure, too much potassium in the blood (hyperkalemia), absence of spontaneous breathing (apnea), respiratory depression, and respiratory failure may rarely occur.
Management: Supportive and symptomatic treatment. Induce emesis with syrup of ipecac or perform gastric lavage. Administer activated charcoal to reduce absorption and reabsorption. Forced alkaline diuresis might be beneficial. Management of hypotension, gastrointestinal bleeding and acidosis may also be necessary.
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