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Folic acid in large doses may interfere with the metabolism of phenobarbital, phenytoin, primidone and may partially reverse the antiepileptic effects of those drugs thereby increasing the frequency of seizures in susceptible patients.
Folic acid may interfere with the metabolism of certain medications, including antineoplastic agents such as methotrexate, oral contraceptive pills, and anti-tuberculosis agents.
Drugs that may interfere with the body's absorption of folic acid are analgesics / pain relievers such as NSAIDs, antibiotics (tetracycline), anticonvulsants (phenytoin, carbamazepine), antacids, epoetin, estrogens, oral contraceptives, methotrexate, pyrimethamine, triamterene, trimethoprim, sulfonamides and zinc supplements. Folic acid may interfere with the absorption of these agents.
Individuals who are taking these agents may need to take folic acid supplements. However, folic acid should be taken at a different time of the day or should not be taken at the same time with folic acid because these drugs interfere with the absorption and effectiveness of folic acid.
