Luvestra Caution For Usage

Special precautions for disposal and other handling: Instructions for administration: Administer the injection according to the local guidelines for performing large volume intramuscular injections.
NOTE: Due to the proximity of the underlying sciatic nerve, caution should be taken if administering Fulvestrant at the dorsogluteal injection site (see Precautions).
Warning: Do not autoclave safety needle before use. Hands must remain behind the needle at all times during use and disposal.
Syringes are supplied with safety needle BD SafetyGlide or Terumo SurGuard.
Instructions for safety needle BD SafetyGlide: For each of the two syringes: Carefully remove the needle and syringe from the packaging.
Remove the protective cap from the tip of the syringe barrel.
Peel open the safety needle (BD SafetyGlide) outer packaging. Attach the safety needle to the Luer-Lock.
Twist to lock the needle to the Luer connector. Twist until firmly sealed.
Pull shield straight off needle to avoid damaging needle point.
Remove needle sheath.
While holding the syringe with the needle pointing upward, gently push in the plunger until the medicine is up to the top of the syringe. There should be no air within the barrel.
Administer intramuscularly slowly (1-2 minutes/injection) into the buttock. For user convenience, the needle bevel-up position is oriented to the lever arm.
After injection, immediately apply a single-finger stroke to the activation assisted lever arm to activate the shielding mechanism.
NOTE: Activate away from self and others. Listen for click and visually confirm needle tip is fully covered.
Instructions for safety needle Terumo SurGuard: For each of the two syringes: Carefully remove the needle and syringe from the packaging.
Remove the protective cap from the tip of the syringe barrel.
Tighten the syringe to the needle using aseptic technique. Grip the base of the needle, not the sheath, and turn the syringe clockwise.
Move the safety shield away from the needle and toward the syringe barrel to the angle. Then remove the needle cap.
While holding the syringe with the needle pointing upward, gently push in the plunger until the medicine is up to the top of the syringe. There should be no air within the barrel.
Administer intramuscularly slowly (1-2 minutes/injection) into the buttock.
After completing the injection, remove the needle from the skin and use a one-handed technique to activate the safety mechanism using any of the three methods: Finger activation, thumb activation, surface activation.
Activation is verified by an audible and/or tactile "click", and can be visually confirmed.
If uncertain that the safety shield is fully engaged, repeat this step.
Disposal: Pre-filled syringes are for single use only.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
Incompatibilities: In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.