Luseco Dosage/Direction for Use

Posology: Usually for adults, 2.5 mg as luseogliflozin should be orally administered once daily before or after breakfast. When the effect is insufficient, the dose can be increased to 5 mg once daily while closely monitoring the clinical course.
Luseogliflozin (Luseco) should be administered with care in patients using other antidiabetic drugs (in particular, sulfonylureas, insulin preparations or GLP-1 receptor agonists) [hypoglycemia may occur with combined use].
In particular, when used with sulfonylureas, insulin preparations or GLP-1 receptor agonists, risk of hypoglycemia may be increased. In combined use with sulfonylureas, insulin preparations or GLP-1 receptor agonists, dose reduction of these drugs should be considered in order to decrease the risk of hypoglycemia associated with them (see Interactions, Adverse Reactions and Pharmacology: Pharmacodynamics under Actions).
Patients with renal impairment: Luseogliflozin (Luseco) should not be administered to patients with severe renal impairment or patients with end-stage renal failure being treated by dialysis because it is not expected to be effective in these patients.
The necessity of administration should be carefully considered in patients with moderate renal impairment because Luseogliflozin (Luseco) may not be sufficiently effective (see Precautions, and Pharmacology: Pharmacodynamics and Pharmacokinetics under Actions).
Patients with hepatic impairment: There is no experience in the use for patients with severe liver dysfunction and safety in these patients has not been established (see Precautions and Pharmacology: Pharmacokinetics under Actions).
Paediatric population: Safety in the use in low-birth-weight babies, neonates, nursing infants, infants, and children has not been established. [There is no experience in the use for the previously mentioned patients.]
Elderly: Because physiological function is generally impaired in elderly patients, Luseogliflozin (Luseco) should be administered carefully while monitoring the conditions of patients.
Because detection of the symptoms of dehydration (including thirst) may be delayed in elderly patients, caution should be exercised (see Precautions).
Method of administration: Luseogliflozin (Luseco) should be orally administered once daily, before or after breakfast.