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Leuprorelin (Luprolex) is contraindicated in women who are or may become pregnant while receiving the drug. Leuprorelin may cause fetal harm when administered to a pregnant woman. Major fetal abnormalities were observed in rabbits but not in rats after administration of leuprorelin throughout gestation. There was increased fetal mortality and decreased fetal weights in rats and rabbits. The effects on fetal mortality are expected consequences of the alterations in hormonal levels brought about by the drug. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
Nursing mothers: It is not known whether Leuprorelin (Luprolex) is excreted in human milk. Because many drugs are excreted in human milk, and because of the effects of Leuprorelin (Luprolex) on lactation and/or the breast-fed child have not been determined, Leuprorelin (Luprolex) should not be used by nursing mothers.
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