Lilac Drug Interactions

No laxative should be taken within 2 hrs of another medication because the desired effect of the other medication may be reduced.
Antacids: Antacids given concurrently with lactulose may inhibit the desired lactulose-induced drop in colonic pH. Therefore, a possible lack of desired effect of treatment should be taken into consideration before such drugs are given concomitantly with lactulose.
Neomycin: In some situations, neomycin administered together with lactulose is more effective than either one alone.
Although, theoretically, the elimination of certain colonic bacteria by neomycin and possibly other anti-infective agents may interfere with the desired degradation of lactulose and thus prevent the acidification of colonic contents. There have been some reports that lactulose-fermenting bacteria are relatively resistant to neomycin, which may explain why a combination could work in some cases. The status of the lactulose-treated patients should be closely monitored in the event of concomitant oral antibiotic therapy.