Levotics CR Adverse Reactions

(1) Adverse reactions of Levodropropizine (LEVOTICS CR) controlled-release tablet: Multi-center, double-dummy, double-blind, randomized, active-controlled, and parallel group phase 3 clinical study was conducted for patients with acute or chronic bronchitis.
Acute bronchitis: Among a total of 136 patients, 10 side effects were reported in 8 patients (11.59%) in the test group (controlled-release tablet), 5 side effects were reported in 5 patients (7.46%) in the control group (normal tablet), 7 adverse drug reactions were reported in 6 patients (8.70%) in the test group, and 4 adverse reactions were reported in 4 patients (5.97%) in the control group. Severe side effects were reported in neither the test group nor the control group.
Chronic bronchitis: Among a total of 136 patients, 8 side effects were reported in 8 patients (11.94%) in the test group (controlled-release tablet), 8 side effects were reported in 8 patients (11.59%) in the control group (normal tablet), 5 adverse drug reactions were reported in 5 patients (7.46%) in the test group, and 2 adverse reactions were reported in 2 patients (2.90%) in the control group. Severe side effects were reported in neither the test group nor the control group.
(2) Adverse reactions of Levodropropizine normal tablet: Gastrointestinal: nausea, heartburn, diarrhea, vomiting.
Central nervous system: fatigue, weakness, dizziness, drowsiness, headache.
Circulatory system: heart palpitations.
Skin: rarely allergic reactions.