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Pharmacology: Pharmacodynamics: Levodropropizine carries out its antitussive activity through an inhibitory action on the release of sensor neuropeptides from C-fibres.
Pharmacokinetics: Absorption and Distribution: Levodropropizine is rapidly absorbed in humans after oral administration and is rapidly distributed in the organism. Radioactivity after oral administration is 93%. The binding with human plasma proteins is 11%-14% and half-life is about 1-2 hours.
Metabolism and Excretion: Levodropropizine is mainly excreted in urine as an unaltered product and its metabolites (conjugated levodropropizine, and free and conjugated p-hydroxy-levodropropizine). The urinary secretion of the product and metabolites in 48 hours is equal to about 35% of the administered dose.
