Levocin Drug Interactions

Nonsteroidal Anti-inflammatory Drugs (NSAIDs): The concomitant administration of NSAIDs with a quinolone, including levofloxacin, may increase the risk of CNS stimulation and convulsive seizures.
Antidiabetic Agents: Disturbances of blood glucose, including hyperglycemia and hypoglycemia have been reported in patients treated concomitantly with quinolones and an antidiabetic agent (e.g., glyburide/glibenclamide) or insulin. Therefore, careful monitoring of blood glucose is recommended when these agents are co-administered.
FC tablet: Antacids, Sucralfate, Metal Cations, Multivitamins: Concurrent administration of levofloxacin with antacids containing magnesium or aluminum, as well as sucralfate metal cations such as iron and multivitamin preparations with zinc may interfere with the gastrointestinal absorption of levofloxacin resulting in systemic levels considerably lower than desired. These agents should be taken at least 2 hours before or 2 hours after levofloxacin administration.
Theophylline, Cyclosporine, Digoxin, Probenecid and Cimetidine: No significant effect of levofloxacin on the plasma concentrations, AUC and other disposition parameters for theophylline, cyclosporine, digoxin, probenecid and cimetidine was detected in a clinical study.
Warfarin: There have been no reports during the post marketing experience in patients that levofloxacin enhances the effects of warfarin. Prothrombin time, International Normalized Ratio (INR) or other suitable anticoagulation tests should be closely monitored if levofloxacin is administered concomitantly with warfarin. Patients should also be monitored for evidence of bleeding.
IV infusion: Multivalent cations: No quinolone should be co-administered with any solution containing multivalent cations, e.g. magnesium, through the same intravenous line.