Adjunctive therapy in treatment of partial seizures w/ or w/o secondary generalization. May also be considered as 2nd-line drug in generalized tonic-clonic seizures in myoclonus including juvenile myoclonic epilepsy & for atonic or tonic seizures.
Gradually w/draw treatment when discontinuing. Assess renal function prior to dose selection in patients w/ severe hepatic impairment. Patients w/ renal impairment may require dose adjustment. Not recommended in women of childbearing potential not using contraception & during pregnancy unless clearly necessary. Breastfeeding is not recommended during treatment.
Inhibited renal clearance of the primary metabolite w/ probenecid & other medicinal products excreted by active tubular secretion. Slightly reduced rate of absorption w/ food.
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