Leveprazole Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Omeprazole Na

Indications/Uses

Conditions where inhibition of gastric acid secretion may be beneficial, including aspiration syndromes, dyspepsia, GERD, PUD & Zollinger-Ellison syndrome.

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Dosage/Direction for Use

Administer by IV inj over 5 min or by IV infusion over 20-30 min. Prophylaxis of acid aspiration 40 mg completed 1 hr before surgery. Benign gastric ulcer, duodenal ulcer & GERD 40 mg once daily until PO is possible. Severe peptic ulcer bleeding Initially 80 mg IV infusion then by continuous IV infusion 8 mg/hr for 72 hr (then change to oral therapy).

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Overdosage

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Contraindications

Hypersensitivity to omeprazole or other PPIs.

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Special Precautions

Consider possibility of malignancy in patients w/ gastric ulcers since PPIs may mask symptoms & delay diagnosis. Exclude gastric malignancy at initiation of treatment & follow-up of gastric ulcer therapy. Gastritis in gastric corpus biopsies from patients on long-term therapy. May increase risk of community-acquired pneumonia. Increased bioavailability in Asian patients; consider dose reduction in those receiving long-term therapy for maintenance of healing of erosive esophagitis. Hepatic impairment. Lactation. Limited experience in childn. Increased sensitivity to drug & risk for potential side effects in elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, diarrhea, & skin rashes. Pruritus, dizziness, fatigue, constipations, nausea & vomiting, flatulence, abdominal pain, arthralgia & myalgia, urticaria & dry mouth. Isolated cases of photosensitivity, bullous eruption, erythema multiforme, angioedema, & anaphylaxis. CNS effects including occasional insomnia, somnolence, & vertigo; reversible confusional states, agitation, depression, & hallucinations in severely ill patients. Raised liver enzymes, & isolated cases of hepatitis, jaundice & hepatic encephalopathy.

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Drug Interactions

May alter metabolism of some drugs metabolized by CYP450 system primarily by isoenzyme CYP2C19. May prolong elimination of diazepam, phenytoin, & warfarin. Can reduce absorption of drugs eg, ketoconazole, & possibly itraconazole. Plasma conc of both drugs may be increased w/ voriconazole, whose absorption is dependent on gastric acid pH.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Leveprazole detailed prescribing information

Storage

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Description

View Leveprazole description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BC01 - omeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Regulatory Classification

Presentation/Packing

Form

Leveprazole powd for inj 40 mg

Packing/Price

(vial + 10 mL diluent) 1's

Leveprazole

omeprazole

Manufacturer:

Rainbow Life Sciences

Distributor:

HLM Pharma

Marketer:

Ambica