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Clinical interaction studies with cimetidine and warfarin indicated that the co-administration of Letrozole with these medicinal products does not result in clinically significant drug interactions. Data from clinical studies do not indicate any further relevant interactions with other commonly prescribed medicinal products.
There is no clinical experience to date on the use of Letrozole in combination with other anticancer agents.
Letrozole inhibits in vitro the cytochrome P450-isoenzymes 2A6 and moderately 2C19. CYP2A6 does not play a major role in the metabolism of medicinal products. Thus, caution should be used in the concomitant administration of medicinal products whose disposition is mainly dependent on these isoenzymes and whose therapeutic index is narrow.
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