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Hypersensitivity to the active substance or to any of the excipients.
Pregnancy and lactation.
Under 18 years of age.
Thrombocytopenia.
Hypersensitivity (symptoms like asthma, rhinitis, angioedema or urticaria) to other NSAIDs including acetylsalicylic acid.
Severe heart failure.
Gastro-intestinal bleeding, cerebrovascular bleeding or other bleeding disorders.
History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy.
Active or history of recurrent peptic ulcer/hemorrhage (two or more distinct episodes of proven ulceration or bleeding).
Severe hepatic impairment.
Severe renal impairment (Serum creatinine > 700 μmol/l).
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