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The liver excretes Clarithromycin. Therefore, caution should be exercised in administering the antibiotic to patients with impaired hepatic function and with moderate to severe renal failure.
Attention should be paid to the possibility of cross-resistance between Clarithromycin and other macrolide drugs, as well as lincomycin and clindamycin.
Clarithromycin should not be used during pregnancy if possible. High doses have been associated with embryo toxicity in animal studies.
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