Prevention & therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection w/ limited protein in food of ≤40 g/day (for adult) ie, generally in patients w/ GFR <25 mL/min.
Regularly monitor serum Ca level. Ensure sufficient supply of cal. Allow a period of at least 2 hr to pass between intake of ketoanalogues + essential amino acids & drugs that form sparingly soluble compd w/ Ca. No experience has been made w/ administration during pregnancy & lactation.
May lead to pathological increases of serum Ca level or intensification w/ simultaneous administration of medicaments containing Ca (eg, acetolyte). Reduce possible administration of Al hydroxide due to improved uraemic symptoms during therapy. Not to be co-administered w/ drugs that form sparingly soluble compd w/ Ca [eg, tetracyclines, quinolones (eg, ciprofloxacin & norfloxacin), Fe fluoride & estramustine-containing drugs]. Increased susceptibility towards heart/cardiac-active glycosides & hence risk of arrhythmia w/ the rise of blood Ca conc.
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